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钙离子通道阻滞剂中毒的治疗:一项系统评价
原作者: Bryan Hayes;郑辛甜翻译,肖锋 发布日期:2015-01-05

 

Title: Treatment for Calcium Channel Blocker Poisoning: A Systematic Review
题目:钙离子通道阻滞剂中毒的治疗:一项系统评价
Author 作者: Bryan Hayes
翻译:郑辛甜 校对:肖锋

 


In a precursor to a forthcoming international guideline on the management of calcium channel blocker poisoning, a new systematic review has been published assessing the available evidence.
作为即将推出的关于钙离子通道阻滞剂中毒管理国际性指南的前奏,一个新的针对已有证据的系统评价现已发表。
A few findings from the systematic review:
以下是这一系统评价中的几项结论:

•The majority of literature on calcium channel blocker overdose management is heterogenous, biased, and low-quality evidence.
•大部分关于钙离子通道阻滞剂中毒治疗的研究文献的证据是不一样的、偏倚的,低质量的。
•Interventions with the strongest evidence are high-dose insulin and extracorporeal life support.
•高剂量胰岛素和体外生命支持干预的证据级别最高。
•Interventions with less evidence, but still possibly beneficial, include calcium, dopamine, norepinephrine, 4-aminopyridine (where available), and lipid emulsion therapy.
•证据级别较低但仍可能有效的干预包括钙、多巴胺、去甲肾上腺素、4-氨基吡啶(如有),及脂质乳剂治疗。
Stay tuned for the international guideline coming out soon. One treatment recommendation from the new guideline, reported at the 8th European Congress on Emergency Medicine last month, is not to use glucagon.
敬请关注即将推出的国际性指南。新指南推荐的一项治疗方法,在上个月第八届欧洲急诊医学会议上有所报道,是不推荐使用胰高血糖素。

References 参考文献:
St-Onge M, et al. Treatment for calcium channel blocker poisoning: a systematic review. Clin Toxicol 2014. [Epub ahead of print].
http://informahealthcare.com/doi/pdf/10.3109/15563650.2014.965827