Title: DKA Deaths Due to 2nd Generation Antipsychotics
题目:由于第二代抗精神病药导致的DKA致死
Author作者: FerminBarrueto
• Hyperglycemia in the setting of antipsychotic use has been reported mostly with olanzapine (Zyprexa) but does occur with other antipsychotics. A recent study from the NYC medical examiner's office details 17 deaths of DKA due to antipsychotics and found that (from highest to lowest incidence) quetiapine> olanzapine >risperidone were the atypical antipsychotics found with these deaths.
• 服用抗精神病药产生的高血糖多与olanzapine(奥氮平)有关,但也可由其它抗精神病药造成。最近一个来自纽约医学检察官办公室的文章详细报到了17例因抗精神病药导致的死亡,发现这些死亡都与非特异抗精神病药有关,包括(按频率顺序)喹硫平,奥氮平,和利培酮(quetiapine,olanzapine,和risperidone)。
• Remember hyperglycemia occurs with patients on antipsychotics and can lead to hyperglycemia hyperosmolar coma or DKA. Both can be lethal.
• 要记住,服用抗精神病药的病人可出现高血糖,导致高血糖高渗性昏迷或DKA。这两个都可致死。
References参考文献:
Fatal Diabetic Ketoacidosis and Antipsychotic Medication.
Ely SF, Neitzel AR, Gill JR.
J Forensic Sci. 2012 Dec 27. doi: 10.1111/1556-4029.12044.