Title: B-Type Natriuretic Peptide
题目:B型利钠肽
Author 作者: Semhar Tewelde
B-type natriuretic peptide (BNP) is a useful prognostic biomarker in patients with reduced LVEF, but data in heart failure (HF) with preserved ejection fraction (HFPEF) is minimal
B型利钠肽(BNP)对有左室功能减低的心衰患者是一个可靠的判断预后的生物指标,但对左室射血分数正常的心力衰竭(HFPEF)病人的数据却非常有限。
A recent study sought to determine the prognostic value of BNP in patients with HFPEF in comparison to data in HF patients with reduced left ventricular EF <40%
最近的一项研究评估了BNP对HFPEF患者的预后价值,并与左室EF<40%的心衰患者的数据进行了比较
615 patients with mild to moderate HF were followed for 18 months and BNP was measured at baseline and related to the primary outcomes (mortality and HF hospitalization)
615例轻度至中度心衰患者在测量了BNP水平后随访了18个月,观察了BNP与主要指标 (死亡率和心衰住院率)的关系
BNP levels were significantly higher in patients with reduced LVEF than in those with HFPEF (p < 0.001), however the risk of adverse outcomes and prognosis in patients with HFPEF is as poor as in those with reduced LVEF
左室EF降低患者的BNP水平明显高于那些HFPEF病人(P <0.001),但是HFPEF患者的预后和那些左室EF降低的病人一样不佳
References 参考文献:
B-Type Natriuretic Peptide and Prognosis in Heart Failure Patients With Preserved and Reduced Ejection Fraction. Veldhuisen D, Linssen G, et al. J Am Coll Cardiol 2013; 61:1498-506